What D80 covers · when clinicians use it
ICD-10 code D80 identifies Immunodeficiency with predominantly antibody defects in the U.S. ICD-10-CM clinical and billing record set. It sits within the Blood & Blood-forming Organs chapter (D50–D89), the section that groups related diagnoses so providers, payers, and public-health agencies report them consistently. Clinicians and medical coders apply D80 when an encounter's findings match the Immunodeficiency with predominantly antibody defects description, attaching it to the patient record so downstream insurance claims, payer audits, quality reporting, and epidemiological surveillance all reference the same standardized diagnosis. The ICD-10-CM is maintained by the Centers for Medicare & Medicaid Services and the CDC's National Center for Health Statistics, with an updated official code set released each U.S. fiscal year — always verify D80 against the current CMS/CDC release and your payer's documentation guidance before final use. This page summarizes documentation context for D80 and is a coding reference, not clinical, diagnostic, or billing advice.
D80 refers to Immunodeficiency with predominantly antibody defects, a category of immune system disorders and procedural complications that affect the body's ability to defend against infections or result from surgical events. These conditions range from genetic immunodeficiencies to immune dysregulation syndromes and post-surgical spleen damage.
Symptoms
- Recurrent infections – Especially respiratory, gastrointestinal, and sinus infections
- Delayed wound healing – From immune impairment
- Unexplained fever or inflammation – Especially in sarcoidosis or immune dysregulation
- Post-surgical bleeding or abscess – For D78 complications
- Autoimmune manifestations – Seen in combined or variable immunodeficiencies
- Lymphadenopathy – Especially in sarcoidosis or chronic immunologic disease
- Fatigue or weakness – From chronic immune dysfunction
Diagnosis
Diagnosis of Immunodeficiency with predominantly antibody defects involves immunoglobulin level testing, flow cytometry, lymphocyte function assays, biopsy (e.g., for sarcoidosis), and imaging for surgical complications. A multidisciplinary approach is often required including immunology, infectious disease, and surgery.
ICD10 Code Usage
ICD10 code D80 is used in immunology, internal medicine, surgery, and oncology to document immune system dysfunctions and spleen-related procedural events. These codes are essential for accurate clinical tracking, immunotherapy eligibility, and billing documentation.
Related Codes
- D78 – Intraoperative and postprocedural complications of the spleen
- D81 – Combined immunodeficiencies
- D82 – Immunodeficiency associated with other major defects
- D83 – Common variable immunodeficiency
- D84 – Other immunodeficiencies
- D86 – Sarcoidosis
- D89 – Other disorders involving the immune mechanism, not elsewhere classified
FAQs
Q1: What is ICD10 code D80?
A: It documents Immunodeficiency with predominantly antibody defects, covering complications of the spleen and primary or acquired immune disorders.
Q2: Are these chronic conditions?
A: Many immune disorders are lifelong, though their severity and treatment options vary greatly.
Q3: What causes immune deficiencies?
A: Genetic mutations, environmental exposures, certain medications, or underlying health conditions.
Q4: How are these disorders managed?
A: Immunoglobulin replacement, infection prophylaxis, immunosuppressants, surgery, and supportive care.
Q5: Who typically manages care?
A: Clinical immunologists, hematologists, infectious disease experts, and surgeons for procedural issues.
Conclusion
ICD10 code D80 is essential for identifying and managing Immunodeficiency with predominantly antibody defects. These codes support timely treatment, help in preventing complications, and allow for consistent tracking in patients with immune system dysfunctions or surgical complications.